Description
GGTase-I (Geranylgeranyltransferase-I) catalyzes the transfer of the farnesyl and geranylgeranyl groups from farnesyl and geranylgeranyl-diphosphate to proteins containing a C-terminal CaaX motif, where ’C’ is a conserved cysteine that is the site of farnesyl modification, ’a’ is usually an aliphatic amino acid, and ’X’ is leucine or phenylalanine